Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 15/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6723833 | 0.99 | PGR (0.54) | PGRNR3C1ARMAOANR3C2 | |
| SCHEMBL6720477 | 0.86 | PGR (0.49) | PGRNR3C1ARNR3C2 | |
| SCHEMBL2397969 | 0.85 | PGR (0.57) | PGRNR3C1ARMAOA | |
| SCHEMBL2393047 | 0.84 | PGR (0.73) | PGRNR3C1ARNR3C2 | |
| SCHEMBL5032324 | 0.84 | PGR (0.53) | PGRNR3C1ARNR3C2 | |
| SCHEMBL6294955 | 0.83 | PGR (0.52) | PGRNR3C1ARNR3C2 | |
| SCHEMBL4160644 | 0.82 | AR (0.53) | PGRNR3C1ARNR3C2 | |
| SCHEMBL1315813 | 0.81 | ESR1 (0.53) | PGRMAOA | |
| SCHEMBL5034870 | 0.81 | PGR (0.51) | PGRNR3C1ARMAOANR3C2 | |
| SCHEMBL7113533 | 0.79 | PGR (0.47) | PGRNR3C1ARNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030069427-A1 | Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro- 1H-chromeno [3,4-f] quinolines and derivatives thereof | ABBVIE INC. | 2003-04-10 | — | — | US | claimed |
| WO-2003027117-A1 | A PROCESS FOR THE PREPARATION OF 5-(SUBSTITUTED)-10-METHOXY-2,2,4-TRIMETHYL-2,5-DIHYDRO-1H-CHROMENO[3,4-F]QUINOLINES AND DERIVATIVES THEREOF | ABBOTT LABORATORIES (US) | 2003-04-03 | — | — | WO | claimed |
| US-6518430-B1 | The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5- dihydro-1H-chromeno(3,4-f)quinolines. | ABBOTT LABORATORIES | 2003-02-11 | — | — | US | claimed |
| US-20220280661-A1 | GLUCOCORTICOID RECEPTOR RADIOLIGANDS AND METHODS FOR THEIR PREPARATION AND USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-09-08 | — | — | US | disclosed |
| WO-2021118728-A2 | GLUCOCORTICOID RECEPTOR RADIOLIGANDS AND METHODS FOR THEIR PREPARATION AND USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-06-17 | — | — | WO | disclosed |
| WO-2021118728-A2 | GLUCOCORTICOID RECEPTOR RADIOLIGANDS AND METHODS FOR THEIR PREPARATION AND USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-06-17 | — | — | WO | disclosed |
| US-6608216-B2 | Preparing biaryl atropisomers; chirality transfer from stereogenic center of secondary alcohol to biaryl stereogenic axis via regioselective intramolecular migration | ABBOTT LABORATORIES | 2003-08-19 | — | — | US | disclosed |
| US-20030073844-A1 | Process for the preparation of chiral glucocorticoid receptor agents | ABBOTT LABORATORIES | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073844-A1 | Process for the preparation of chiral glucocorticoid receptor agents | NR3C1, NR3C2, MC2R | PGR 286/4885NR3C1 1/4885AR 35/4885 |
| US-20030069427-A1 | Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro- 1H-chromeno [3,4-f] quinolines and derivatives thereof | HTR3C, CYP3A5, NQO2 | PGR 3676/4885NR3C1 4111/4885AR 3247/4885 |
| US-20220280661-A1 | GLUCOCORTICOID RECEPTOR RADIOLIGANDS AND METHODS FOR THEIR PREPARATION AND USE | NR3C1, NR3C2, MC2R | PGR 116/4885NR3C1 1/4885AR 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.