SCHEMBL693026

SCHEMBL693026

C1=Cc2cccc3cccc-3c2C1

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PRCP P42785 1/20 0.34
PARP10 Q53GL7 1/20 0.34
PARP11 Q9NR21 1/20 0.34
SLC6A2 P23975 1/20 0.33
HTR2A P28223 1/20 0.33
SLC6A4 P31645 1/20 0.33
HRH1 P35367 1/20 0.33
OPRD1 P41143 1/20 0.33
OPRK1 P41145 1/20 0.33
HTR2B P41595 1/20 0.33
HTR3A P46098 1/20 0.33
SLC6A3 Q01959 1/20 0.33
HTR1A P08908 2/20 0.30
HTR7 P34969 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6912627 0.96 PRCP (0.40) PRCPPARP10PARP11HTR1AHTR7
SCHEMBL27868971 0.86 PRCP (0.31) PRCPPARP10PARP11SLC6A2HTR2A
SCHEMBL28802253 0.82 PTAFR (0.37)
SCHEMBL28316529 0.81 BRD4 (0.34) HTR1A
SCHEMBL20204270 0.77 RXRA (0.36) HTR1AHTR7
SCHEMBL8167759 0.76 HTR7 (0.34) PARP10PARP11SLC6A2HTR2ASLC6A4
SCHEMBL27717319 0.76 PRCP (0.41) PRCPPARP10PARP11HTR1AHTR7
SCHEMBL5068750 0.76 PRCP (0.38) PRCPPARP10PARP11HTR1AHTR7
SCHEMBL11084798 0.75 LTK (0.49) HTR1AHTR7
SCHEMBL6930009 0.75 HTR7 (0.39) SLC6A2HTR2ASLC6A4HRH1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6774078-B1 COMPLEX INCORPORATES A GROUP 3-10 TRANSITION METAL AND AN ANNULATED CYCLOPENTADIENYL LIGAND THAT IS PI-BONDED TO THE METAL EQUISTAR CHEMICALS, LP 2004-08-10 US claimed
CN-102459282-A Thia-triaza-cyclopentazulenes as PI 3-kinase inhibitors for the treatment of cancer BOEHRINGER INGELHEIM INT 2012-05-16 CN disclosed
EP-2421871-A1 THIA-TRIAZA-CYCLOPENTAZULENES AS PI3-KINASES INHIBITORS FOR THE TREATMENT OF CANCER Boehringer Ingelheim International GmbH (DE) 2012-02-29 EP disclosed
WO-2010122071-A1 THIA-TRIAZA-CYCLOPENTAZULENES AS PI3-KINASES INHIBITORS FOR THE TREATMENT OF CANCER BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-10-28 WO disclosed
US-6774078-B1 COMPLEX INCORPORATES A GROUP 3-10 TRANSITION METAL AND AN ANNULATED CYCLOPENTADIENYL LIGAND THAT IS PI-BONDED TO THE METAL EQUISTAR CHEMICALS, LP 2004-08-10 US disclosed