SCHEMBL6930357

SCHEMBL6930357

O=C(O)C1NN(c2ccccc2)C(=O)C1(O)O

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALOX12 P18054 2/20 0.35
GAA P10253 8/20 0.35
ALDH1A1 P00352 4/20 0.35
KDM4E B2RXH2 3/20 0.35
GFER P55789 2/20 0.35
LMNA P02545 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
RECQL P46063 1/20 0.33
NOTUM Q6P988 1/20 0.33
GSK3A P49840 1/20 0.32
GSK3B P49841 1/20 0.32
PTPRA P18433 1/20 0.32
ELANE P08246 1/20 0.32
METAP2 P50579 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6934396 0.83 ALDH1A1 (0.40) GAAALDH1A1KDM4EGFERLMNA
SCHEMBL6933827 0.80 MEN1 (0.42) ALOX12GAAALDH1A1KDM4EL3MBTL1
SCHEMBL6931469 0.77 CA2 (0.35) ALOX12GAAALDH1A1KDM4EGFER
SCHEMBL6932553 0.74 GAA (0.35) ALOX12GAAALDH1A1KDM4EGFER
SCHEMBL6932528 0.74 GAA (0.38) ALOX12GAAALDH1A1KDM4EGFER
SCHEMBL6932809 0.74 GAA (0.35) ALOX12GAAALDH1A1KDM4EGFER
SCHEMBL6933179 0.74 ALOX12 (0.33) ALOX12GAAALDH1A1KDM4EGFER
SCHEMBL6931202 0.74 ALDH1A1 (0.41) GAAALDH1A1KDM4EGFERLMNA
SCHEMBL6932814 0.71 ELANE (0.37) ALOX12GAAALDH1A1KDM4EGFER
SCHEMBL8489871 0.71 KMT2A (0.40) GAAALDH1A1KDM4ELMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0903342-B1 4,4-Dihydroxypyrazolin-5-one compounds, procedures for their preparation and their use as cosmetics OREAL (FR) 2003-12-17 EP claimed
EP-0903342-A1 4,4-Dihydroxypyrazolin-5-one compounds, procedures for their preparation and their use as cosmetics L'OREAL (FR) 1999-03-24 EP claimed
EP-0903342-B1 4,4-Dihydroxypyrazolin-5-one compounds, procedures for their preparation and their use as cosmetics OREAL (FR) 2003-12-17 EP disclosed
EP-0903342-A1 4,4-Dihydroxypyrazolin-5-one compounds, procedures for their preparation and their use as cosmetics L'OREAL (FR) 1999-03-24 EP disclosed