Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202004 | 0.93 | DPP4 (0.45) | LTA4HMEN1KMT2AYAP1LNPEP | |
| SCHEMBL6933977 | 0.87 | LTA4H (0.48) | LTA4HAGTR2LNPEPDPP4FAP | |
| SCHEMBL6935180 | 0.86 | DPP4 (0.47) | LTA4HYAP1LNPEPDPP4FAP | |
| SCHEMBL7905108 | 0.85 | GPR132 (0.43) | LTA4HMEN1KMT2AYAP1DPP4 | |
| SCHEMBL6930651 | 0.84 | AGTR2 (0.43) | LTA4HMEN1KMT2AYAP1AGTR2 | |
| SCHEMBL6934867 | 0.82 | LTA4H (0.39) | LTA4HDPP4DPP8DPP7 | |
| SCHEMBL6935321 | 0.82 | DPP4 (0.45) | LTA4HYAP1LNPEPDPP4FAP | |
| SCHEMBL6935894 | 0.82 | YAP1 (0.48) | LTA4HYAP1LNPEPDPP4FAP | |
| SCHEMBL6934215 | 0.80 | DPP4 (0.42) | LTA4HYAP1LNPEPDPP4FAP | |
| SCHEMBL7908667 | 0.79 | DPP4 (0.44) | LTA4HYAP1ALDH1A1SMN1; SMN2LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984981-B1 | ANTI-INFLAMMATORY TYROSINE DERIVATIVES | CELLTECH THERAPEUTICS LTD (GB) | 2003-12-17 | — | — | EP | disclosed |
| US-6093696-A | N-ACETYL-D-THIOPROLINE-(O-2,6-DICHLOROBENZYL)-L-TYROSINE, FOR EXAMPLE; SELECTIVELY INHIBIT THE ALPHA 4 SUBGROUP OF INTEGRINS FROM BINDING TO THEIR LIGANDS; USE IN PROPHYLAXIS OR TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |