Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | FAP | Q12884 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 6/20 | 0.42 |
| ▸ | LAP3 | P28838 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930978 | 0.93 | LTA4H (0.46) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL7905108 | 0.92 | GPR132 (0.43) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL6935180 | 0.91 | DPP4 (0.47) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL6930651 | 0.90 | AGTR2 (0.43) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL6935321 | 0.89 | DPP4 (0.45) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL6935894 | 0.86 | YAP1 (0.48) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL6933977 | 0.86 | LTA4H (0.48) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL6934215 | 0.85 | DPP4 (0.42) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL7908667 | 0.85 | DPP4 (0.44) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL7896696 | 0.83 | RAB9A (0.44) | DPP4FAPDPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6093696-A | N-ACETYL-D-THIOPROLINE-(O-2,6-DICHLOROBENZYL)-L-TYROSINE, FOR EXAMPLE; SELECTIVELY INHIBIT THE ALPHA 4 SUBGROUP OF INTEGRINS FROM BINDING TO THEIR LIGANDS; USE IN PROPHYLAXIS OR TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |