Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 8/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.37 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6933966 | 0.87 | ITGB1 (0.37) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL7906150 | 0.87 | SLC7A5 (0.43) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL7906184 | 0.87 | SLC7A5 (0.52) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL8200203 | 0.87 | TPH1 (0.38) | SLC7A5PTPN1 | |
| SCHEMBL7896737 | 0.86 | SLC7A5 (0.41) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL6935180 | 0.86 | DPP4 (0.47) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL7904116 | 0.85 | SLC7A5 (0.45) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL6931396 | 0.85 | SLC7A5 (0.34) | SLC7A5PRSS1TMPRSS15PTPN1 | |
| SCHEMBL6936891 | 0.84 | S1PR5 (0.47) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL7902836 | 0.84 | ITGA4 (0.35) | PRSS1TMPRSS15PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984981-B1 | ANTI-INFLAMMATORY TYROSINE DERIVATIVES | CELLTECH THERAPEUTICS LTD (GB) | 2003-12-17 | — | — | EP | disclosed |
| US-6093696-A | N-ACETYL-D-THIOPROLINE-(O-2,6-DICHLOROBENZYL)-L-TYROSINE, FOR EXAMPLE; SELECTIVELY INHIBIT THE ALPHA 4 SUBGROUP OF INTEGRINS FROM BINDING TO THEIR LIGANDS; USE IN PROPHYLAXIS OR TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |