Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 6/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | TPH1 | P17752 | 2/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.34 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6931396 | 0.92 | SLC7A5 (0.34) | ITGB1ITGA4ITGB7SLC7A5PTPN1 | |
| SCHEMBL7902836 | 0.91 | ITGA4 (0.35) | ITGB1ITGA5ITGA4ITGB7PTPN1 | |
| SCHEMBL8200203 | 0.89 | TPH1 (0.38) | SLC7A5PTPN1TPH1 | |
| SCHEMBL6931447 | 0.87 | CTSL (0.40) | SLC7A5PTPN1ALPIPKMPTGS1 | |
| SCHEMBL6933976 | 0.86 | ITGA4 (0.46) | ITGB1ITGA4 | |
| SCHEMBL7908715 | 0.85 | FNTA (0.33) | — | |
| SCHEMBL6930616 | 0.84 | BLM (0.35) | PRSS1TMPRSS15NPC1RAB9AKMT2A | |
| SCHEMBL7902869 | 0.84 | ITGB1 (0.38) | ITGB1ITGA5ITGA4ITGB7SLC7A5 | |
| SCHEMBL7905098 | 0.84 | ITGB1 (0.50) | ITGB1ITGA4ITGB7 | |
| SCHEMBL6930981 | 0.82 | ITGB1 (0.39) | ITGB1ITGA5ITGA4ITGB7PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984981-B1 | ANTI-INFLAMMATORY TYROSINE DERIVATIVES | CELLTECH THERAPEUTICS LTD (GB) | 2003-12-17 | — | — | EP | disclosed |
| US-6093696-A | N-ACETYL-D-THIOPROLINE-(O-2,6-DICHLOROBENZYL)-L-TYROSINE, FOR EXAMPLE; SELECTIVELY INHIBIT THE ALPHA 4 SUBGROUP OF INTEGRINS FROM BINDING TO THEIR LIGANDS; USE IN PROPHYLAXIS OR TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |