Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 3/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.53 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.53 |
| ▸ | FRK | P42685 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847695 | 0.87 | ALDH1A1 (0.46) | CSNK1DMAPK9MAP4K4CDC42BPAMINK1 | |
| SCHEMBL5790262 | 0.84 | MAPK14 (0.45) | CSNK1DMAPK9MAP4K4CDC42BPAMINK1 | |
| SCHEMBL4816410 | 0.83 | MAPK14 (0.54) | CSNK1DMAPK9MAP4K4CDC42BPAMINK1 | |
| SCHEMBL5787744 | 0.83 | CSNK1D (0.55) | CSNK1DMAPK9MAP4K4CDC42BPAMINK1 | |
| SCHEMBL5792669 | 0.79 | MAPK14 (0.68) | ALDH1A1KDM4ELMNAMAPK14MAPK13 | |
| SCHEMBL27224359 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNAMAPK14MAPK13 | |
| SCHEMBL6933235 | 0.74 | MAPK14 (0.53) | ALDH1A1KDM4ELMNAMAPK14MAPK13 | |
| SCHEMBL5786968 | 0.72 | CDC7 (0.47) | CSNK1DMAPK9MAP4K4CDC42BPAMINK1 | |
| SCHEMBL5786878 | 0.71 | MAPK14 (0.50) | CSNK1DMAPK9MAP4K4CDC42BPAMINK1 | |
| SCHEMBL5786467 | 0.71 | MAPK14 (0.44) | ALDH1A1KDM4ELMNAMAPK14TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649604-B2 | Analgesics; antidiabetic agents; antiinflamamtory agents | AMGEN INC. | 2003-11-18 | — | — | US | disclosed |
| EP-1037881-B1 | PROCESS OF PREPARING SUBSTITUTED PYRIMIDINONES | AMGEN INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | AMGEN INC. | 2003-04-17 | — | — | US | disclosed |
| US-6420385-B1 | INFLAMMATORY, PAIN AND DIABETES DISEASES, | AMGEN INC. | 2002-07-16 | — | — | US | disclosed |
| EP-1037881-A1 | PROCESS OF PREPARING SUBSTITUTED PYRIMIDINONES | Amgen Inc. (US) | 2000-09-27 | — | — | EP | disclosed |
| US-6096753-A | Substituted pyrimidinone and pyridone compounds and methods of use | AMGEN INC. (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1999028303-A1 | PROCESS OF PREPARING SUBSTITUTED PYRIMIDINONES | AMGEN, INC. (US) | 1999-06-10 | — | — | WO | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | IL6, IL1B, IL1A | CSNK1D 1761/4885MAPK9 1247/4885MAP4K4 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.