Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847695 | 0.79 | ALDH1A1 (0.46) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL5740391 | 0.78 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL27224359 | 0.77 | ALDH1A1 (0.60) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL5792669 | 0.77 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL4816410 | 0.74 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL6932152 | 0.74 | CSNK1D (0.53) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL1843091 | 0.71 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL5790262 | 0.71 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL3743033 | 0.70 | GSK3B (0.50) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11504223 | 0.69 | CSNK2A2 (0.44) | ALDH1A1KDM4ELMNAMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649604-B2 | Analgesics; antidiabetic agents; antiinflamamtory agents | AMGEN INC. | 2003-11-18 | — | — | US | disclosed |
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | AMGEN INC. | 2003-04-17 | — | — | US | disclosed |
| US-6420385-B1 | INFLAMMATORY, PAIN AND DIABETES DISEASES, | AMGEN INC. | 2002-07-16 | — | — | US | disclosed |
| US-6096753-A | Substituted pyrimidinone and pyridone compounds and methods of use | AMGEN INC. (US) | 2000-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | IL6, IL1B, IL1A | MAPK14 1169/4885MAPK13 1577/4885MAPK12 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.