Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29253491 | 0.84 | ADRB1 (0.46) | SIGMAR1KMT2AMEN1ADRB1HTR3A | |
| SCHEMBL613703 | 0.83 | HPGD (0.51) | KMT2AMEN1KDM1ATSHRALDH1A1 | |
| SCHEMBL6933020 | 0.82 | ADRB1 (0.47) | POLBADRB1HTR3ASMN1; SMN2MAPT | |
| SCHEMBL6934619 | 0.81 | CYP1A2 (0.46) | SIGMAR1POLBKMT2AMEN1HTR3E | |
| SCHEMBL24528365 | 0.79 | RAB9A (0.53) | KMT2AMEN1TSHRALDH1A1AKR1C3 | |
| SCHEMBL13165368 | 0.79 | RAB9A (0.53) | KMT2AMEN1TSHRALDH1A1AKR1C3 | |
| SCHEMBL6931654 | 0.78 | ADRB1 (0.45) | SIGMAR1POLBKMT2AADRB1HTR3A | |
| Bromide SCHEMBL4354126 | 0.76 | SIGMAR1 (0.45) | SIGMAR1POLBKMT2AMEN1HTR3E | |
| SCHEMBL9354442 | 0.76 | SIGMAR1 (0.45) | SIGMAR1POLBKMT2AMEN1HTR3E | |
| SCHEMBL6931863 | 0.76 | ALDH1A1 (0.48) | KMT2AMEN1ADRB1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366030-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS | Neurogen Corporation (US) | 2003-12-03 | — | — | EP | claimed |
| WO-2002004433-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-17 | — | — | WO | claimed |