Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934619 | 0.84 | CYP1A2 (0.46) | ADRB1HTR2CTDP1TP53HTR1A | |
| SCHEMBL6932180 | 0.82 | SIGMAR1 (0.47) | ADRB1HTR3AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL29253491 | 0.81 | ADRB1 (0.46) | ADRB1GABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL6931863 | 0.78 | ALDH1A1 (0.48) | ADRB1HTR2CTP53MAPTSMN1; SMN2 | |
| SCHEMBL11483281 | 0.77 | GPR183 (0.52) | NPC1MAPTPOLBRAB9AL3MBTL1 | |
| SCHEMBL11483277 | 0.77 | GPR183 (0.52) | NPC1MAPTPOLBRAB9AL3MBTL1 | |
| SCHEMBL6931871 | 0.74 | TDP1 (0.50) | TDP1PTGS1PTGS2SMN1; SMN2L3MBTL1 | |
| SCHEMBL6931654 | 0.72 | ADRB1 (0.45) | ADRB1HTR2CTP53HTR1AHTR3A | |
| SCHEMBL30268861 | 0.70 | TP53 (0.56) | TDP1TP53NPC1CASP3SENP8 | |
| SCHEMBL27567537 | 0.70 | TP53 (0.56) | TDP1TP53NPC1CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366030-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS | Neurogen Corporation (US) | 2003-12-03 | — | — | EP | claimed |
| WO-2002004433-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-17 | — | — | WO | claimed |