Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965716 | 0.92 | MEN1 (0.45) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7408997 | 0.83 | MAPT (0.46) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL28303519 | 0.80 | PLA2G7 (0.46) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL176946 | 0.77 | TRPV4 (0.57) | CYP11B1CYP11B2TRPV4ESR1ESR2 | |
| SCHEMBL11011101 | 0.77 | CA12 (0.43) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL31122790 | 0.75 | TRPV4 (0.55) | CYP11B1CYP11B2TRPV4ESR1ESR2 | |
| SCHEMBL26335081 | 0.75 | MAPT (0.49) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8118733 | 0.74 | KAT6A (0.37) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL27957723 | 0.74 | MAPT (0.50) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL2476400 | 0.74 | MRGPRX4 (0.47) | MAPTMEN1LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363876-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | Abbott Laboratories (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002064550-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | ABBOTT LABORATORIES (US) | 2002-08-22 | — | — | WO | disclosed |