Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.44 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932984 | 0.83 | MAPT (0.43) | MAPTHPGDALDH1A1GAAMEN1 | |
| SCHEMBL2476400 | 0.81 | MRGPRX4 (0.47) | MAPTHPGDMEN1LMNAKMT2A | |
| SCHEMBL3965716 | 0.81 | MEN1 (0.45) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL29509997 | 0.79 | MAPT (0.53) | MAPTHPGDALDH1A1GAAMEN1 | |
| SCHEMBL10612278 | 0.79 | XDH (0.42) | MAPTHPGDALDH1A1GAAMEN1 | |
| SCHEMBL4252680 | 0.78 | GLA (0.49) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL21728104 | 0.77 | ALDH1A1 (0.46) | MAPTHPGDALDH1A1GAAMEN1 | |
| SCHEMBL28303519 | 0.77 | PLA2G7 (0.46) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL5901307 | 0.77 | MAOB (0.48) | MAPTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL23795076 | 0.76 | MAOB (0.53) | MAPTHPGDALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000069844-A1 | OLIGOHYDROXYL SUBSTITUTED BENZOFURAN-3-YL AND PYRIDOFURANYLUREA DERIVATIVES AS PHOSPHODIESTERASE IV INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-11-23 | — | — | WO | disclosed |
| US-6124343-A | Substituted phenyl compounds with a substituent having a thienyl ring | RHONE-POULENC RORER LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0805802-B1 | SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS | RHONE POULENC RORER LTD (GB) | 2000-08-16 | — | — | EP | disclosed |
| US-6048893-A | Substituted phenyl compounds with a substituent having A 1,3-benzodioxole ring | RHONE-POULENC RORER LIMITED (GB) | 2000-04-11 | — | — | US | disclosed |
| CN-1178525-A | Substituted phenyl compounds as endothelin antagonists | RHONE POULEUC RORER LTD (GB) | 1998-04-08 | — | — | CN | disclosed |
| EP-0805802-A1 | SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS | RHONE-POULENC RORER LIMITED (GB) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022978-A1 | SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS | RHONE POULENC RORER LIMITED (GB) | 1996-08-01 | — | — | WO | disclosed |