Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24648579 | 0.92 | F10 (0.48) | PPARGPPARAPTGS1PTGS2L3MBTL1 | |
| SCHEMBL8654136 | 0.92 | HSP90AA1 (0.50) | ALDH1A1HPGDCNR2HSP90AA1HSP90AB1 | |
| SCHEMBL24648555 | 0.86 | LMNA (0.52) | PPARGPPARATDP1ALDH1A1CNR2 | |
| SCHEMBL10704144 | 0.83 | AKR1B1 (0.58) | PTGS1PTGS2L3MBTL1ATMTDP1 | |
| SCHEMBL13114560 | 0.83 | ALDH1A1 (0.53) | ALDH1A1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL2003391 | 0.83 | POLB (0.53) | PTGS2L3MBTL1ALDH1A1HPGDHSP90AA1 | |
| SCHEMBL11356019 | 0.83 | KDM4E (0.54) | PPARGPPARAPTGS1PTGS2L3MBTL1 | |
| SCHEMBL17179972 | 0.81 | PKM (0.61) | PTGS1PTGS2L3MBTL1ATMTDP1 | |
| SCHEMBL5973730 | 0.81 | MAPK14 (0.46) | PTGS2TDP1ALDH1A1RAB9AHPGD | |
| SCHEMBL9616832 | 0.80 | PKM (0.68) | ALDH1A1HPGDMEN1KMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787777-B1 | Crown ether amines and methods of use | PALL CORPORATION (US) | 2023-10-17 | — | — | US | disclosed |
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787777-B1 | Crown ether amines and methods of use | H1-2, H1-0, CNR1 | PPARG 3926/4885PPARA 4216/4885PTGS1 2700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.