Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.45 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935937 | 0.88 | SLC6A4 (0.40) | RAB9ASLC6A4PDE7ASLC9A1MAPT | |
| SCHEMBL8796619 | 0.88 | PDE7A (0.50) | LMNASLC6A4PDE7ASLC9A1MAPT | |
| SCHEMBL27531424 | 0.87 | LMNA (0.48) | LMNAALDH1A1RAB9ASLC6A4PDE7A | |
| SCHEMBL6937471 | 0.87 | SLC6A4 (0.47) | LMNAALDH1A1RAB9ASLC6A4PDE7A | |
| SCHEMBL6932303 | 0.85 | MAPT (0.40) | LMNAALDH1A1SLC6A4PDE7ASLC9A1 | |
| SCHEMBL6938143 | 0.84 | BCL2L1 (0.48) | ALDH1A1PDE7AUSP7SLC9A1MAPT | |
| SCHEMBL7075292 | 0.84 | PDE7A (0.46) | LMNARAB9APDE7AUSP7SLC9A1 | |
| SCHEMBL6935074 | 0.81 | SLC6A2 (0.42) | LMNAALDH1A1RAB9ASLC6A4SLC9A1 | |
| SCHEMBL7074544 | 0.81 | ALDH1A1 (0.49) | LMNAALDH1A1SLC9A1MAPTL3MBTL1 | |
| SCHEMBL6935462 | 0.80 | SLC9A1 (0.40) | ALDH1A1SLC6A4PDE7ASLC9A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |