SCHEMBL6933397

SCHEMBL6933397

Cc1cccc(-c2cc(N)ccc2N)c1-c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 1/20 0.44
ALDH1A1 P00352 5/20 0.42
HSD17B10 Q99714 4/20 0.42
MAOA P21397 1/20 0.41
HTR7 P34969 1/20 0.41
ANPEP P15144 1/20 0.40
DPP4 P27487 1/20 0.40
CD44 P16070 1/20 0.38
CASP1 P29466 1/20 0.38
NPC1 O15118 4/20 0.38
RAB9A P51151 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
TP53 P04637 2/20 0.38
TSHR P16473 2/20 0.38
CYP3A4 P08684 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
MAPK1 P28482 1/20 0.38
MYC P01106 1/20 0.38
KDM4E B2RXH2 2/20 0.37
MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL55383 0.89 HSD17B10 (0.46) ALDH1A1HSD17B10MAOAHTR7NPC1
SCHEMBL173368 0.82 PLA2G7 (0.56) PLA2G7ALDH1A1HSD17B10HTR7ANPEP
SCHEMBL6926189 0.82 PLA2G7 (0.42) PLA2G7ALDH1A1HSD17B10MAOAANPEP
SCHEMBL28298181 0.81 MAOA (0.47) PLA2G7ALDH1A1HSD17B10MAOAHTR7
Hydrochloric Acid SCHEMBL6570879 0.80 PLA2G7 (0.55) PLA2G7ALDH1A1HSD17B10HTR7ANPEP
SCHEMBL27745845 0.78 ALDH1A1 (0.58) PLA2G7ALDH1A1HSD17B10MAOANPC1
SCHEMBL29208409 0.78 RAB9A (0.42) PLA2G7ALDH1A1HSD17B10NPC1RAB9A
Hydrochloric Acid SCHEMBL6574527 0.77 PLA2G7 (0.43) PLA2G7ALDH1A1HSD17B10ANPEPDPP4
SCHEMBL2833305 0.77 ALDH1A1 (0.47) PLA2G7ALDH1A1HSD17B10MAOACASP1
SCHEMBL6931570 0.76 ALDH1A1 (0.45) PLA2G7ALDH1A1HSD17B10MAOACASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1186595-B1 Diaryl-p-phenylenediamine disulfides GOODYEAR TIRE & RUBBER (US) 2003-11-26 EP disclosed
US-6627686-B1 Mixture with rubber; oxidation resistance; tires, rolls, conveyor belts, footwear THE GOODYEAR TIRE & RUBBER COMPANY 2003-09-30 US disclosed
EP-1186595-A1 Diaryl-p-phenylenediamine disulfides THE GOODYEAR TIRE & RUBBER COMPANY (US) 2002-03-13 EP disclosed
EP-0700963-B1 Polymeric N-aryl substituted and N-alkaryl substituted diphenyldiamines GOODYEAR TIRE & RUBBER (US) 1999-04-14 EP disclosed
US-5726248-A ANTIOXIDANTS FOR DIENE POLYMERS WITH HIGH MOLECULAR WEIGHTS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1998-03-10 US disclosed
EP-0700963-A1 Polymeric N-aryl substituted and N-alkaryl substituted diphenyldiamines THE GOODYEAR TIRE & RUBBER COMPANY (US) 1996-03-13 EP disclosed