Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6931605 | 0.82 | HTR3A (0.49) | KDM4ELMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4866793 | 0.76 | KMT2A (0.44) | CYP1A2CYP1A1CYP1B1ALDH1A1KMT2A | |
| SCHEMBL6931871 | 0.75 | TDP1 (0.50) | GAAKDM4ESMN1; SMN2CYP1A2CYP1A1 | |
| SCHEMBL27567539 | 0.74 | CYP1A2 (0.66) | KDM4ECYP1A2CYP1A1CYP1B1ALDH1A1 | |
| SCHEMBL4753301 | 0.72 | TSHR (0.59) | KDM4ELMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL6933867 | 0.70 | ALDH1A1 (0.47) | GAAKDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL27909079 | 0.70 | JUN (0.44) | GAAKDM4ELMNASMN1; SMN2CYP1A2 | |
| SCHEMBL7192327 | 0.70 | CYP1A2 (0.63) | GAAKDM4ECYP1A2CYP1A1CYP1B1 | |
| SCHEMBL6909563 | 0.69 | ALDH1A1 (0.64) | GAAKDM4ESMN1; SMN2CYP1A2CYP1A1 | |
| SCHEMBL233151 | 0.69 | HTR3A (0.71) | LMNAKMT2AMAPTHTR3AHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366030-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS | Neurogen Corporation (US) | 2003-12-03 | — | — | EP | claimed |
| WO-2002004433-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-17 | — | — | WO | claimed |