Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.51 |
| ▸ | ITGAV | P06756 | 8/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099306 | 0.92 | ITGB3 (0.51) | ITGB3ITGAVITGA2BMEN1KMT2A | |
| SCHEMBL7104753 | 0.90 | ITGB3 (0.51) | ITGB3ITGAVITGA2BMEN1KMT2A | |
| SCHEMBL7104882 | 0.86 | ITGB3 (0.51) | ITGB3ITGAVITGA2BNPC1RAB9A | |
| SCHEMBL7105223 | 0.85 | ITGB3 (0.55) | ITGB3ITGAVITGA2BNPC1RAB9A | |
| SCHEMBL6779560 | 0.82 | ITGB3 (0.50) | ITGB3ITGAVITGA2B | |
| SCHEMBL6934969 | 0.81 | ITGB3 (0.51) | ITGB3ITGAVITGA2BMEN1KMT2A | |
| SCHEMBL7879691 | 0.81 | ITGB3 (0.56) | ITGB3ITGAVITGA2BMEN1KMT2A | |
| SCHEMBL7100980 | 0.81 | ITGB3 (0.42) | ITGB3ITGAVITGA2BMEN1KMT2A | |
| SCHEMBL7099697 | 0.79 | ITGB3 (0.68) | ITGB3ITGAVITGA2BSMN1; SMN2 | |
| SCHEMBL13059983 | 0.78 | ITGB3 (0.66) | ITGB3ITGAVITGA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649613-B1 | Integrin inhibitors | MERCK PATENT GMBH (DE) | 2003-11-18 | — | — | US | disclosed |
| EP-1194401-B1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-09-10 | — | — | EP | disclosed |