SCHEMBL6934972

SCHEMBL6934972

NS(=O)(=O)c1cc2c[c]c(=O)[nH]c2cc1F

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CA2 P00918 6/20 0.37
CA12 O43570 4/20 0.37
CA1 P00915 4/20 0.37
CA9 Q16790 3/20 0.37
ILK Q13418 2/20 0.32
CA7 P43166 1/20 0.31
CA13 Q8N1Q1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6935366 0.84
SCHEMBL6938296 0.81 CA1 (0.42) CA2CA12CA1CA9CA7
SCHEMBL6935418 0.81 CA2 (0.46) CA2CA12CA1CA9CA7
Phosphonic Acid SCHEMBL7070319 0.76 CA1 (0.41) CA2CA12CA1CA9CA7
SCHEMBL6939756 0.70 GRIN2D (0.33)
SCHEMBL6927156 0.70 DAO (0.33) CA2CA12CA1CA9
SCHEMBL6923608 0.70 CA1 (0.36) CA2CA12CA1CA9CA7
SCHEMBL6934908 0.69 TRPV4 (0.38) CA2CA12CA1CA9CA7
SCHEMBL6937670 0.66 KIF11 (0.35)
SCHEMBL4067022 0.66 CA2 (0.38) CA2CA12CA1CA9CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1125941-B1 Derivatives of 6-sulfamoyl-3-quinolyl phosphonic acids, process for their preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2003-04-09 EP disclosed
EP-1125941-A1 Derivatives of 6-sulfamoyl-3-quinolyl phosphonic acids, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 2001-08-22 EP disclosed