Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.56 |
| ▸ | HTR3B | O95264 | 3/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.56 |
| ▸ | HTR6 | P50406 | 9/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821267 | 0.83 | ADRA1D (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7821698 | 0.82 | HTR3A (0.57) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL2349863 | 0.82 | HTR3A (0.69) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL7708526 | 0.81 | HTR3A (0.68) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL4754004 | 0.80 | HTR6 (0.66) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL966017 | 0.79 | HTR6 (0.65) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL6772998 | 0.78 | LIPE (0.48) | HTR6LMNAMAPTHTR1A | |
| SCHEMBL6777684 | 0.77 | ADRA1D (0.48) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL22892354 | 0.77 | HTR3A (0.57) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7832918 | 0.76 | HTR3A (0.62) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226131-B1 | ISOXAZOLECARBOXAMIDE DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-12-17 | — | — | EP | disclosed |
| EP-1200445-B1 | THIENOPYRANECARBOXAMIDE DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-09-17 | — | — | EP | disclosed |
| EP-1222183-B1 | BENZOPYRAN DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-04-23 | — | — | EP | disclosed |
| US-20020193381-A1 | Thienopyranecarboxamide derivatives | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY | 2002-12-19 | — | — | US | disclosed |
| US-6387909-B1 | VISION DEFECTS; BENIGN PROSTATIC HYPERPLASIA | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-05-14 | — | — | US | disclosed |
| US-6306861-B1 | ANTISPASMODIC AGENTS AND TREATMENT OF INCONSTANCE | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2001-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193381-A1 | Thienopyranecarboxamide derivatives | ADRA1D, ADRB3, OPRD1 | HTR3A 101/4885HTR3E 254/4885HTR3B 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.