Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.44 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046976 | 0.86 | CYSLTR2 (0.45) | LTB4RLTB4R2MAPTCYP3A4ALDH1A1 | |
| SCHEMBL27677557 | 0.82 | KDM4E (0.39) | MAPTMEN1NR1I2LMNACHRM2 | |
| SCHEMBL9196144 | 0.81 | LTB4R (0.60) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL8957148 | 0.80 | PRKCI (0.41) | MAPTLMNAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL29283569 | 0.80 | HMGCR (0.36) | LTB4RLTB4R2MAPTLMNAKDM4E | |
| SCHEMBL27556628 | 0.78 | NNMT (0.44) | NNMTMAPTLMNACYP3A4KDM4E | |
| SCHEMBL8878063 | 0.78 | ACHE (0.44) | LTB4RLTB4R2NNMTMAPTMEN1 | |
| SCHEMBL30645263 | 0.78 | NNMT (0.39) | LTB4RLTB4R2NNMTMAPTMEN1 | |
| SCHEMBL23630667 | 0.77 | ALOX5 (0.51) | MAPTMEN1NR1I2LMNACHRM2 | |
| SCHEMBL8210818 | 0.77 | ALOX5 (0.51) | MAPTMEN1NR1I2LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |