SCHEMBL6936394

SCHEMBL6936394

NC(F)(F)c1ccc(F)c(F)c1F

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
KIF11 P52732 1/20 0.32
MPL P40238 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8160495 0.79 PDE2A (0.40) CES2CES1KIF11MPL
SCHEMBL3972408 0.78 HSD11B1 (0.38) CES2CES1KIF11MPL
SCHEMBL578143 0.77 CES2 (0.36) CES2CES1
SCHEMBL206670 0.77 CES2 (0.41) CES2CES1KIF11
SCHEMBL2074175 0.75 CES2 (0.34) CES2CES1
SCHEMBL2973848 0.75 CES2 (0.34) CES2CES1KIF11
SCHEMBL1201613 0.75 CES2 (0.39) CES2CES1KIF11
SCHEMBL2974322 0.75 CES2 (0.39) CES2CES1KIF11
SCHEMBL4409844 0.75 CES2 (0.34) CES2CES1KIF11
SCHEMBL11255717 0.75 CES2 (0.34) CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-63258452-A None JP disclosed
CN-114015063-B Nitro-ligand-doped zeolitic imidazolate framework material ZIF-71-clnIm x Preparation and use of 太原理工大学 2023-01-10 CN disclosed
CN-114751807-A Novel efficient preparation process of 2,3,5, 6-tetrafluorobenzyl alcohol 忠同科技(大连)有限公司 2022-07-15 CN disclosed
CN-114015063-A Nitro-ligand-doped zeolitic imidazolate framework material ZIF-71-clnImxPreparation and use of 太原理工大学 2022-02-08 CN disclosed
EP-0910380-B1 SUBSTITUTED BENZYLIDENE INDENYL FORMAMIDES, ACETAMIDES AND PROPIONAMIDES CELL PATHWAYS INC (US) 2003-08-13 EP disclosed
US-6403831-B1 5,6-DIFLUORO-2-METHYL-1-(3,4,5-TRIMETHOXY-BENZYLIDENE)-3-(N-BE NZYL)-INDENYL ACETAMIDE; ANTITUMOR AND ANTICARCINOGENIC AGENT USED TO TREAT PRECANCEROUS LESIONS CELL PATHWAYS, INC. 2002-06-11 US disclosed
EP-0819000-A4 NODULISPORIC ACID DERIVATIVES MERCK & CO INC (US) 2001-04-11 EP disclosed
EP-0910380-A4 SUBSTITUTED BENZYLIDENE INDENYL FORMAMIDES, ACETAMIDES AND PROPIONAMIDES CELL PATHWAYS INC (US) 2000-09-27 EP disclosed
US-6063818-A Substituted benzylidene indenyl formamides, acetamides and propionamides CELL PATHWAYS INC. (US) 2000-05-16 US disclosed
US-5962499-A ACARICIDAL, ANTIPARASITIC, INSECTICIDAL AND ANTHELMINTIC AGENTS MERCK & CO., INC. (US) 1999-10-05 US disclosed
WO-1996029073-A1 NODULISPORIC ACID DERIVATIVES MERCK & CO., INC. (US) 1996-09-26 WO disclosed
EP-0452055-B1 Surfaces with reduced protein interactions HEWLETT PACKARD CO (US) 1995-01-11 EP disclosed
EP-0377649-B1 HALOGENATED SURFACE WITH REDUCED PROTEIN INTERACTION Hewlett-Packard Company (US) 1993-03-10 EP disclosed
US-5114768-A Electrophoretic protein separation HEWLETT-PACKARD COMPANY (US) 1992-05-19 US disclosed
EP-0452055-A1 Surfaces with reduced protein interactions Hewlett-Packard Company (US) 1991-10-16 EP disclosed
US-5006313-A Halogenated surface with reduced protein interaction HEWLETT-PACKARD COMPANY (US) 1991-04-09 US disclosed
EP-0377649-A1 HALOGENATED SURFACE WITH REDUCED PROTEIN INTERACTION. HEWLETT PACKARD CO (US) 1990-07-18 EP disclosed
WO-1989012225-A1 HALOGENATED SURFACE WITH REDUCED PROTEIN INTERACTION HEWLETT-PACKARD COMPANY (US) 1989-12-14 WO disclosed
JP-S63258452-A MONOMER CONTAINING FLUORINATED AROMATIC GROUP AND POLYMER PRODUCED THEREFROM NIPPON SHOKUBAI KAGAKU KOGYO CO LTD 1988-10-25 JP disclosed
US-3946063-A 2,3,4,5,6-PENTAFLUOROBENZYL CHLOROFORMATE PIERCE CHEMICAL COMPANY (US) 1976-03-23 US disclosed