SCHEMBL456092

SCHEMBL456092

Nc1ccc(NCc2ccco2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 0.58
KDM4E B2RXH2 5/20 0.58
ALDH1A1 P00352 4/20 0.58
MAPK1 P28482 4/20 0.58
LMNA P02545 3/20 0.58
HPGD P15428 2/20 0.58
PKM P14618 1/20 0.58
ALOX15 P16050 1/20 0.58
TSHR P16473 1/20 0.58
HSD17B10 Q99714 1/20 0.58
MAPT P10636 5/20 0.50
TDP1 Q9NUW8 1/20 0.50
KCNH3 Q9ULD8 3/20 0.49
SHMT2 P34897 1/20 0.47
SMN1; SMN2 Q16637 4/20 0.46
KMT2A Q03164 3/20 0.46
MEN1 O00255 1/20 0.46
HTT P42858 1/20 0.46
BLM P54132 1/20 0.46
MAOA P21397 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10992513 0.98 GAA (0.56) GAAKDM4EALDH1A1MAPK1LMNA
SCHEMBL2805209 0.82 ALDH1A1 (0.68) GAAKDM4EALDH1A1MAPK1LMNA
SCHEMBL11318597 0.82 GAA (0.47) GAAKDM4EALDH1A1MAPK1LMNA
SCHEMBL10657204 0.81 ALDH1A1 (0.60) GAAKDM4EALDH1A1MAPK1LMNA
SCHEMBL11792458 0.81 SMN1; SMN2 (0.59) GAAKDM4EALDH1A1MAPK1LMNA
SCHEMBL693662 0.81 NPC1 (0.59) GAAKDM4EALDH1A1MAPK1LMNA
SCHEMBL4422314 0.80 ALDH1A1 (0.56) GAAKDM4EALDH1A1MAPK1LMNA
SCHEMBL22129234 0.80 ALDH1A1 (0.65) GAAKDM4EALDH1A1MAPK1LMNA
Hydrochloric Acid SCHEMBL454706 0.80 NPC1 (0.58) GAAKDM4EALDH1A1MAPK1LMNA
SCHEMBL15455447 0.78 ALDH1A1 (0.54) GAAKDM4EALDH1A1MAPK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1752192-B1 Oxidizing hair coloring agents containing m-Aminophenol derivatives PROCTER & GAMBLE (US) 2010-02-03 EP claimed
US-20070067923-A1 1,3-Diaminobenzene derivatives and colorants comprising these compounds PROCTER & GAMBLE COMPANY, THE 2007-03-29 US claimed
EP-1760072-A1 1,3-diaminobenzene derivatives and colorants comprising these compounds Wella Aktiengesellschaft (DE) 2007-03-07 EP claimed
US-20070033745-A1 Developer substance-coupler substance of 3-(1-pyrrolidinyl)phenol and 1,4-diaminobenzene PROCTER & GAMBLE COMPANY, THE 2007-02-15 US claimed
EP-1752192-A1 Oxidizing hair coloring agents containing m-Aminophenol derivatives Wella Aktiengesellschaft (DE) 2007-02-14 EP claimed
US-20070022546-A1 3-Amino-2-aminomethylphenol derivatives and colorants comprising these compounds PROCTER & GAMBLE COMPANY, THE 2007-02-01 US claimed
US-5540738-A SIMULTANEOUSLY APPLYING IODIDE IONS, AN OXIDANT AND AN EFFECTIVE CONCENTRATION OF AN OXIDATION DYE TO PRODUCE INTENSE COLORS IN ALKALINE SOLUTION CHAN ALEXANDER C (US) 1996-07-30 US claimed
EP-0545257-B1 Oxidative hair coloring compositions and process for dyeing human keratinous fibers BRISTOL MYERS SQUIBB CO (US) 1996-05-29 EP claimed
EP-0545257-A2 Oxidative hair coloring compositions and process for dyeing human keratinous fibers BRISTOL-MYERS SQUIBB COMPANY (US) 1993-06-09 EP claimed
EP-4719411-A2 QUINOLINEAMINE AND PYRIDOQUINOLINE ANTIDEGRADANT COMPOUNDS AND USES THEREOF Flexsys IP Holdings, LLC (US) 2026-04-08 EP disclosed
EP-4638590-A2 RUBBER COMPOSITIONS COMPRISING ANTIDEGRADANTS FLEXSYS AMERICA L.P. (US) 2025-10-29 EP disclosed
WO-2024249718-A2 QUINOLINEAMINE AND PYRIDOQUINOLINE ANTIDEGRADANT COMPOUNDS AND USES THEREOF FLEXSYS AMERICA L.P. (US) 2024-12-05 WO disclosed
US-12133906-B2 Delivery particle THE PROCTER & GAMBLE COMPANY (US) 2024-11-05 US disclosed
WO-2024137665-A2 RUBBER COMPOSITIONS COMPRISING ANTIDEGRADANTS FLEXSYS AMERICA L.P. (US) 2024-06-27 WO disclosed
EP-0507448-A2 Oxidative hair dyeing process with catalytic pretreatment Bristol-Myers Squibb Company (US) 1992-10-07 EP disclosed
US-5100436-A Transition metal complex of 2,2*-dipyridine or 1,10-phenanthroline deposited on hair, reduced time for coloring CLAIROL INCORPORATED (US) 1992-03-31 US disclosed
US-5032138-A Chlorites as oxidants in hair coloring CLAIROL INCORPORATED (US) 1991-07-16 US disclosed
EP-0399746-A1 Use of chlorites as oxidants in hair coloring Bristol-Myers Squibb Company (US) 1990-11-28 EP disclosed
US-4566875-A HAIR DYES L'OREAL (FR) 1986-01-28 US disclosed
US-4425132-A HAIR DYES, APPLYING WITHOUT RINSING L'OREAL (FR) 1984-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070022546-A1 3-Amino-2-aminomethylphenol derivatives and colorants comprising these compounds KRT18, COL2A1, COL1A1 GAA 3251/4885KDM4E 295/4885ALDH1A1 402/4885
US-20070067923-A1 1,3-Diaminobenzene derivatives and colorants comprising these compounds KRT18, DSP, DSG1 GAA 2771/4885KDM4E 2209/4885ALDH1A1 12/4885
US-20070033745-A1 Developer substance-coupler substance of 3-(1-pyrrolidinyl)phenol and 1,4-diaminobenzene TACR1, KRT18, AKR1C4 GAA 4835/4885KDM4E 1548/4885ALDH1A1 8/4885
US-12133906-B2 Delivery particle LIPA, CHMP4B, SLC46A1 GAA 347/4885KDM4E 4662/4885ALDH1A1 1476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.