Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 2/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 4/20 | 0.42 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936727 | 0.84 | KLK5 (0.57) | ITGA4ITGB7KLK5TDP1PAX8 | |
| SCHEMBL8497138 | 0.84 | KLK5 (0.57) | ITGA4ITGB7KLK5TDP1PAX8 | |
| SCHEMBL7452177 | 0.84 | KLK5 (0.57) | ITGA4ITGB7KLK5TDP1PAX8 | |
| SCHEMBL7455375 | 0.84 | KLK5 (0.48) | KLK5TDP1MEN1KMT2ACTSS | |
| SCHEMBL5926274 | 0.83 | CTSS (0.57) | ITGA4ITGB7KLK5CTSSCTSK | |
| SCHEMBL25832689 | 0.82 | NAMPT (0.49) | KMT2ACTSSCTSKMAPTIDO1 | |
| SCHEMBL27331529 | 0.78 | CTSS (0.56) | ITGA4ITGB7KLK5CTSSCTSK | |
| SCHEMBL7520488 | 0.77 | LTA4H (0.45) | MEN1KMT2AHDAC8ALDH1A1LMNA | |
| SCHEMBL30841324 | 0.77 | ITGA4 (0.52) | ITGA4ITGB7KLK5CTSSCTSK | |
| SCHEMBL27332108 | 0.77 | ITGA4 (0.52) | ITGA4ITGB7KLK5CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973945-A4 | CHIRAL PEPTIDE NUCLEIC ACIDS AND METHODS FOR PREPARING SAME | ISIS PHARMACEUTICALS INC (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0973945-A1 | CHIRAL PEPTIDE NUCLEIC ACIDS AND METHODS FOR PREPARING SAME | ISIS PHARMACEUTICALS, INC. (US) | 2000-01-26 | — | — | EP | disclosed |
| US-6015887-A | PREPARING SYNTHETIC MONOMERS BY DEHYDRATIVE COUPLING OF AMINE AND ALCOHOL STARTING REAGENTS | ISIS PHARMACEUTICALS, INC. (US) | 2000-01-18 | — | — | US | disclosed |
| WO-1998046794-A1 | CHIRAL PEPTIDE NUCLEIC ACIDS AND METHODS FOR PREPARING SAME | ISIS PHARMACEUTICALS, INC. (US) | 1998-10-22 | — | — | WO | disclosed |