Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939057 | 0.86 | SLC6A4 (0.42) | SLC6A4SLC6A3HSD11B1TRPA1LMNA | |
| SCHEMBL5163207 | 0.86 | OPRM1 (0.44) | SLC6A4SLC6A3LMNAGAASLC6A2 | |
| SCHEMBL5160386 | 0.86 | OPRM1 (0.44) | SLC6A4SLC6A3HSD11B1LMNAGAA | |
| SCHEMBL27486372 | 0.81 | TRPA1 (0.53) | SLC6A3HSD11B1TRPA1TSHR | |
| SCHEMBL5159940 | 0.74 | OPRM1 (0.40) | SLC6A4SLC6A3SLC6A2TSHRSLC6A9 | |
| SCHEMBL5158611 | 0.74 | OPRM1 (0.41) | SLC6A4SLC6A3TRPA1SLC6A2SLC6A9 | |
| SCHEMBL6941375 | 0.72 | OPRM1 (0.41) | SLC6A4SLC6A3SLC6A2TSHRSLC6A9 | |
| SCHEMBL6938750 | 0.72 | OPRM1 (0.40) | SLC6A4SLC6A3SLC6A2TSHRSLC6A9 | |
| SCHEMBL6936968 | 0.71 | KCNN4 (0.37) | SLC6A4SLC6A3SLC6A2OPRM1OPRL1 | |
| SCHEMBL5158062 | 0.71 | OPRM1 (0.41) | SLC6A4SLC6A3SLC6A2TSHRSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |