SCHEMBL6937174

SCHEMBL6937174

O=C(NNS(=O)(=O)c1cc2c[c]c(=O)[nH]c2cc1Cl)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 15/20 0.46
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
BCAT1 P54687 3/20 0.43
ALDH1A1 P00352 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6937623 0.89 FLT1 (0.43) CA12CA1CA2CA9
SCHEMBL6940270 0.80 KAT6A (0.44) KAT6ACA12CA1CA2CA9
SCHEMBL6937183 0.79 PGR (0.48)
SCHEMBL6941830 0.77 KDM4E (0.30) CA1CA2ALDH1A1SMN1; SMN2
SCHEMBL6940575 0.77 KAT6A (0.43) KAT6ACA12CA1CA2CA9
SCHEMBL6939748 0.76 AR (0.38) CA12CA1CA2CA9
SCHEMBL7645895 0.75 BCAT1 (0.39) KAT6ACA12CA1CA2CA9
SCHEMBL6941462 0.75 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2
SCHEMBL6937780 0.72 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2
SCHEMBL7645899 0.72 BCAT1 (0.37) KAT6ACA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1125942-B1 Derivatives of 6-amino or 6-hydrazinosulfonyl-3-quinolyl phosphonic acids, process for their preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2003-04-09 EP claimed
EP-1125942-A1 Derivatives of 6-amino or 6-hydrazinosulfonyl-3-quinolyl phosphonic acids, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 2001-08-22 EP claimed
EP-1125942-B1 Derivatives of 6-amino or 6-hydrazinosulfonyl-3-quinolyl phosphonic acids, process for their preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2003-04-09 EP disclosed
EP-1125942-A1 Derivatives of 6-amino or 6-hydrazinosulfonyl-3-quinolyl phosphonic acids, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 2001-08-22 EP disclosed