SCHEMBL6938229

SCHEMBL6938229

Cn1c(C(F)(F)F)cc(-c2cc(OCC(=O)O)c(Cl)cc2F)c1Br

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PKM P14618 2/20 0.41
CYP2C19 P33261 1/20 0.39
PTGDR2 Q9Y5Y4 11/20 0.39
TDP1 Q9NUW8 2/20 0.38
TSHR P16473 1/20 0.38
RORC P51449 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
HTT P42858 1/20 0.37
HSD17B10 Q99714 1/20 0.37
AKR1B1 P15121 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6934929 0.88 PPOX (0.46) PKMTDP1TSHRKDM4EALDH1A1
SCHEMBL6937089 0.81 PGK1 (0.35)
SCHEMBL6940513 0.81 CYP2C19 (0.38) PKMCYP2C19PTGDR2TDP1TSHR
SCHEMBL6939948 0.79 CYP2C19 (0.38) PKMCYP2C19PTGDR2TDP1TSHR
SCHEMBL6937395 0.76 HSD11B1 (0.32)
SCHEMBL6937330 0.76 PTGDR2 (0.39) PKMCYP2C19PTGDR2TDP1TSHR
SCHEMBL10577900 0.74 PKM (0.40) PKMCYP2C19PTGDR2TDP1TSHR
SCHEMBL6909703 0.74 PKM (0.44) PKMCYP2C19PTGDR2TDP1TSHR
SCHEMBL6938036 0.72 CYP2C19 (0.38) PKMCYP2C19PTGDR2TDP1TSHR
SCHEMBL31118325 0.71 TDP1 (0.49) PKMCYP2C19PTGDR2TDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1061072-B1 Pyrrolic compounds with a high herbicidal activity and their agronomic use ISAGRO RICERCA SRL (IT) 2003-05-14 EP disclosed
US-6391827-B1 CONTROLLING WEEDS ISAGRO RICERCA S.R.L. (IT) 2002-05-21 US disclosed
EP-1061072-A1 Pyrrolic compounds with a high herbicidal activity and their agronomic use ISAGRO RICERCA S.r.l. (IT) 2000-12-20 EP disclosed