Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 5/20 | 0.57 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | TLR3 | O15455 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559235 | 0.86 | KCNE1 (0.52) | KCNE1KCNQ1KCNH2MAOBPPARA | |
| SCHEMBL6559231 | 0.79 | KCNE1 (0.52) | KCNE1KCNQ1KCNH2MAOBPPARA | |
| SCHEMBL6559307 | 0.79 | KCNE1 (0.59) | KCNE1KCNQ1KCNH2MAOB | |
| SCHEMBL6937137 | 0.76 | KCNE1 (0.55) | KCNE1KCNQ1TLR3MAOBMAOA | |
| SCHEMBL6936890 | 0.75 | KCNE1 (0.58) | KCNE1KCNQ1KCNH2MAOBPPARA | |
| SCHEMBL4011395 | 0.75 | TLR3 (0.42) | KCNE1KCNQ1TLR3CTSDBACE1 | |
| SCHEMBL6931989 | 0.73 | KCNE1 (0.68) | KCNE1KCNQ1KCNH2MAOB | |
| SCHEMBL6560822 | 0.73 | KDM4E (0.62) | MAOBALDH1A1KDM4EGLAGAA | |
| SCHEMBL6558676 | 0.73 | KDM4E (0.45) | KCNE1KCNQ1KCNH2MAOBALDH1A1 | |
| SCHEMBL6558667 | 0.73 | KDM4E (0.45) | KCNE1KCNQ1KCNH2MAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0913396-B1 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6008245-A | TREATMENT OF PROPHYLAXIS AND CARDIOVASCULAR DISORDERS, IN PARTICULAR ARRHYTHMIAS, FOR THE TREATMENT OF ULCERS OF THE GASTROINTESTINAL DISORDERS, DIARRHEAL DISEASES | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 1999-12-28 | — | — | US | disclosed |
| EP-0913396-A2 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-06 | — | — | EP | disclosed |