Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943822 | 0.98 | ADAM17 (0.35) | ADAM17MMP1MMP9MMP13CTSC | |
| SCHEMBL6943842 | 0.87 | P2RX3 (0.32) | — | |
| SCHEMBL6942474 | 0.86 | P2RX3 (0.33) | — | |
| SCHEMBL6939584 | 0.74 | ADAM17 (0.36) | ADAM17MMP1MMP9MMP13CTSC | |
| SCHEMBL7937181 | 0.71 | ADAM17 (0.35) | ADAM17MMP1MMP9MMP13CTSC | |
| SCHEMBL6939934 | 0.69 | ADAM17 (0.36) | ADAM17MMP1MMP9MMP13CTSC | |
| SCHEMBL6940940 | 0.66 | ADAM17 (0.35) | ADAM17MMP1MMP9MMP13CTSC | |
| SCHEMBL6943958 | 0.65 | ADAM17 (0.34) | ADAM17CTSC | |
| SCHEMBL6944520 | 0.63 | HDAC3 (0.36) | ADAM17CTSC | |
| SCHEMBL6942160 | 0.63 | ADAM17 (0.37) | ADAM17MMP1MMP9MMP13CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |