Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942474 | 0.99 | P2RX3 (0.33) | P2RX3TGFBR1 | |
| SCHEMBL6943822 | 0.87 | ADAM17 (0.35) | — | |
| SCHEMBL6939399 | 0.87 | ADAM17 (0.35) | — | |
| SCHEMBL6947932 | 0.82 | TGFBR1 (0.33) | P2RX3TGFBR1 | |
| SCHEMBL7937124 | 0.76 | P2RX3 (0.32) | P2RX3TGFBR1 | |
| SCHEMBL7928806 | 0.75 | P2RX3 (0.34) | P2RX3TGFBR1 | |
| SCHEMBL6946176 | 0.74 | TGFBR1 (0.33) | P2RX3TGFBR1 | |
| SCHEMBL6945851 | 0.73 | P2RX3 (0.32) | P2RX3TGFBR1 | |
| SCHEMBL6948116 | 0.73 | TGFBR1 (0.32) | P2RX3TGFBR1 | |
| SCHEMBL7934868 | 0.73 | CTSC (0.35) | P2RX3TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |