Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.57 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215453 | 0.88 | NR1H4 (0.63) | ITGB1ITGA4SMN1; SMN2NR1H4NPSR1 | |
| SCHEMBL7215467 | 0.83 | NR1H4 (0.67) | ITGB1ITGA4SMN1; SMN2NR1H4NPSR1 | |
| SCHEMBL7046284 | 0.80 | SMN1; SMN2 (0.56) | ITGB1ITGA4SMN1; SMN2TP53NPSR1 | |
| SCHEMBL7046280 | 0.80 | SMN1; SMN2 (0.56) | ITGB1ITGA4SMN1; SMN2TP53NPSR1 | |
| SCHEMBL6955487 | 0.79 | NR1H4 (0.70) | NR1H4TP53NR4A2MAPTKDM4E | |
| SCHEMBL6602394 | 0.79 | SMN1; SMN2 (0.57) | ITGB1ITGA4SMN1; SMN2NPSR1KMT2A | |
| SCHEMBL3499309 | 0.75 | NR1H4 (0.58) | ITGB1ITGA4SMN1; SMN2NR1H4NR4A2 | |
| SCHEMBL7050289 | 0.74 | ITGA4 (0.45) | ITGB1ITGA4SMN1; SMN2NR1H4NPSR1 | |
| SCHEMBL7017204 | 0.74 | TP53 (0.47) | NR1H4TP53 | |
| SCHEMBL7483584 | 0.74 | SMN1; SMN2 (0.69) | SMN1; SMN2NR1H4KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206463-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-29 | — | — | EP | disclosed |
| EP-1206465-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1206463-A1 | FATTY ACID SYNTHASE INHIBITORS | SmithKline Beecham Corporation (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1206465-A1 | FATTY ACID SYNTHASE INHIBITORS | SmithKline Beecham Corporation (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001014364-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-01 | — | — | WO | disclosed |
| WO-2001014362-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-01 | — | — | WO | disclosed |