Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909005 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1RAB9A | |
| SCHEMBL2208410 | 0.83 | MAOA (0.62) | SMN1; SMN2ALDH1A1RAB9AKMT2AMAPT | |
| SCHEMBL3654464 | 0.83 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1RAB9A | |
| SCHEMBL6974312 | 0.83 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1RAB9A | |
| SCHEMBL8422956 | 0.81 | NR4A2 (0.60) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1RAB9A | |
| SCHEMBL6685478 | 0.79 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1RAB9A | |
| SCHEMBL7046284 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1KDM4EITGB1ITGA4 | |
| SCHEMBL6940065 | 0.79 | ITGB1 (0.57) | SMN1; SMN2ALDH1A1KDM4ERAB9AITGB1 | |
| SCHEMBL7046280 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1KDM4EITGB1ITGA4 | |
| SCHEMBL3659048 | 0.78 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296711-B2 | Substituted isoxazole amide compounds as inhibitors of stearoyl-CoA desaturase 1 (SCD1) | HOFFMAN-LA ROCHE INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150307463-A1 | SUBSTITUTED ISOXAZOLE AMIDE COMPOUNDS AS INHIBITORS OF STEAROYL-COA DESATURASE 1 (SCD1) | HOFFMANN-LA ROCHE INC. | 2015-10-29 | — | — | US | disclosed |
| EP-2925751-A1 | SUBSTITUTED ISOXAZOLE AMIDE COMPOUNDS AS INHIBITORS OF STEAROYL-COA DESATURASE 1 (SCD1) | F. Hoffmann-La Roche AG (CH) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014086704-A1 | SUBSTITUTED ISOXAZOLE AMIDE COMPOUNDS AS INHIBITORS OF STEAROYL-COA DESATURASE 1 (SCD1) | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-12 | — | — | WO | disclosed |
| EP-1066316-B1 | CINNAMIC ACID DERIVATIVES HAVING CELL ADHESION MODULATING ACTIVITY | CELLTECH THERAPEUTICS LTD (GB) | 2004-05-12 | — | — | EP | disclosed |
| US-20030220392-A1 | Fatty acid synthase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-11-27 | — | — | US | disclosed |
| US-6559179-B1 | Tinvention relates to the use of compounds as inhibitors of the fatty acid synthase FabH. | SMITHKLINE BEECHAM CORPORATION | 2003-05-06 | — | — | US | disclosed |
| EP-1299376-A1 | FATTY ACID SYNTHASE INHIBITORS | Smithkline Beecham (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-1206463-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-29 | — | — | EP | disclosed |
| EP-1206465-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1206464-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6486192-B1 | Indole compounds useful for treating bacterial infections | SMITHKLINE BEECHAM CORPORATION | 2002-11-26 | — | — | US | disclosed |
| EP-1206463-A1 | FATTY ACID SYNTHASE INHIBITORS | SmithKline Beecham Corporation (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1206464-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1206465-A1 | FATTY ACID SYNTHASE INHIBITORS | SmithKline Beecham Corporation (US) | 2002-05-22 | — | — | EP | disclosed |
| US-6329362-B1 | MODULATION CELL ADHESION THE COMPOUNDS ARE ABLE TO INHIBIT THE BINDING OF ALPHA 4 INTEGRINS TO THEIR LIGANDS AND ARE OF USE IN THE PROPHYLAXIS AND TREATMENT OF IMMUNE OR INFLAMMATORY DISORDERS. | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |
| WO-2001090099-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |
| WO-2001014364-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-01 | — | — | WO | disclosed |
| WO-2001014362-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-01 | — | — | WO | disclosed |
| WO-2001014363-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220392-A1 | Fatty acid synthase inhibitors | FASN, FADS1, FADS2 | SMN1; SMN2 4708/4885ALDH1A1 985/4885KDM4E 2316/4885 |
| US-20150307463-A1 | SUBSTITUTED ISOXAZOLE AMIDE COMPOUNDS AS INHIBITORS OF STEAROYL-COA DESATURASE 1 (SCD1) | SCD, SCD5, CPT1A | SMN1; SMN2 2050/4885ALDH1A1 245/4885KDM4E 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.