SCHEMBL6940127

SCHEMBL6940127

O=C(c1cccc(Cl)c1)N1CCOCC1

nearest known ligand 0.71

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PHGDH O43175 1/20 0.66
PKM P14618 2/20 0.65
ALDH1A1 P00352 3/20 0.64
HPGD P15428 3/20 0.64
NPC1 O15118 1/20 0.64
LMNA P02545 1/20 0.64
MAPT P10636 1/20 0.64
HTT P42858 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
L3MBTL1 Q9Y468 2/20 0.62
KDM4E B2RXH2 2/20 0.61
TSHR P16473 1/20 0.59
RECQL P46063 1/20 0.59
AKR1C3 P42330 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10720509 0.88 L3MBTL1 (0.71) PHGDHPKMALDH1A1HPGDLMNA
SCHEMBL10726894 0.88 PKM (0.74) PKMALDH1A1LMNAHTTSMN1; SMN2
SCHEMBL11858440 0.85 ALDH1A1 (0.58) PKMALDH1A1HTTSMN1; SMN2L3MBTL1
SCHEMBL19519176 0.83 SMN1; SMN2 (0.59) PHGDHALDH1A1HPGDNPC1LMNA
SCHEMBL3457036 0.83 ALDH1A1 (0.70) PKMALDH1A1HPGDNPC1L3MBTL1
SCHEMBL29944586 0.83 ALDH1A1 (0.70) PKMALDH1A1HPGDNPC1L3MBTL1
SCHEMBL28294867 0.83 HPGD (0.71) PKMALDH1A1HPGDLMNAMAPT
SCHEMBL7069211 0.82 HPGD (0.71) PKMALDH1A1HPGDNPC1SMN1; SMN2
(3-Chlorophenyl)(Morpholino)Methanethione SCHEMBL19357196 0.82 KMT2A (0.71) PHGDHALDH1A1HPGDNPC1MAPT
SCHEMBL30957421 0.82 HPGD (0.71) PKMALDH1A1HPGDNPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1352731-A2 Method of orienting polymer molecules MISSISSIPPI POLYMER TECHNOLOGIES, INC. (US) 2003-10-15 EP disclosed
EP-0629217-B1 RIGID-ROD POLYMERS MISSISSIPPI POLYMER TECHNOLOGI (US) 2003-05-07 EP disclosed
US-6087467-A POLY-P-PHENYLENE AND SOLUBLE ORGANIC GROUPS MAXDEM INCORPORATED (US) 2000-07-11 US disclosed
US-5976437-A POLYPHENYL RESINS WITH PENDANT SOLUBILIZING GROUPS; MELT, WET, AND DRY-JET WET SPINNING; ORIENTING BY DRAWING OR STRETCHING; COATING SOLID ARTICLES MAXDEM INCORPORATED (US) 1999-11-02 US disclosed
US-5789521-A POLYPHENYL RESINS MAXDEM INCORPORATED (US) 1998-08-04 US disclosed
US-5760131-A IMPROVING THE FIRE RESISTANCE BY BLENDING WITH A POLYPHENYL RESINS MAXDEM INCORPORATED (US) 1998-06-02 US disclosed
US-5756581-A Rigid-rod polymers MAXDEM INCORPORATED (US) 1998-05-26 US disclosed
US-5731400-A FABRICATING FREE STANDING FILM OF SOLUBLE RIGID ROD POLYETHER SUBSTITUTED WITH SOLUBILIZING SIDE GROUP BY MELTING POLYMER AND EXTRUDING THROUGH SLIT MAXDEM INCORPORATED (US) 1998-03-24 US disclosed
US-5721335-A COMPRESSION MOLDING A POLYPHENYL RESIN HOMO- OR COPOLYMER; MELT PROCESSABILITY MAXDEM INCORPORATED (US) 1998-02-24 US disclosed
US-5654392-A POLYPHENYL RESINS HAVING SOLUBILIZING SIDE GROUPS MAXDEM INCORPORATED (US) 1997-08-05 US disclosed
US-5646232-A MANUFACTURING POLYPHENYL RESINS MAXDEM INCORPORATED (US) 1997-07-08 US disclosed
US-5646231-A POLYPHENYL RESINS MAXDEM, INCORPORATED (US) 1997-07-08 US disclosed
EP-0629217-A4 RIGID-ROD POLYMERS. MAXDEM INC (US) 1995-03-29 EP disclosed
EP-0629217-A1 RIGID-ROD POLYMERS MAXDEM INCORPORATED (US) 1994-12-21 EP disclosed
WO-1993018076-A1 RIGID-ROD POLYMERS MAXDEM INCORPORATED (US) 1993-09-16 WO disclosed
WO-1993018077-A1 RIGID-ROD POLYMERS MAXDEM INCORPORATED (US) 1993-09-16 WO disclosed