Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 9/20 | 0.50 |
| ▸ | METAP1 | P53582 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 7/20 | 0.39 |
| ▸ | CTSL | P07711 | 6/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563124 | 0.82 | METAP2 (0.50) | METAP2METAP1 | |
| SCHEMBL6488117 | 0.77 | METAP2 (0.69) | METAP2METAP1KDM4EALDH1A1POLB | |
| SCHEMBL7361134 | 0.77 | METAP2 (0.64) | METAP2METAP1CTSSCTSLCTSK | |
| Hydrochloric Acid SCHEMBL7358295 | 0.77 | METAP2 (0.63) | METAP2METAP1KDM4EALDH1A1POLB | |
| SCHEMBL6940184 | 0.76 | METAP2 (0.49) | METAP2METAP1CTSSPTGIR | |
| SCHEMBL6934858 | 0.74 | METAP2 (0.46) | METAP2METAP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL7356284 | 0.72 | METAP2 (0.61) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7350513 | 0.71 | METAP2 (0.60) | METAP2METAP1 | |
| SCHEMBL21484760 | 0.71 | KDM4E (0.47) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL7360474 | 0.70 | METAP2 (0.66) | METAP2METAP1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | claimed |