Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.56 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | FCER2 | P06734 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 6/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942387 | 0.87 | ADAM17 (0.71) | ADAM17MMP2MMP13MMP14FCER2 | |
| SCHEMBL6942091 | 0.83 | ADAM17 (0.46) | ADAM17MMP2MMP13MMP9MMP8 | |
| SCHEMBL6945862 | 0.80 | ADAM17 (0.53) | ADAM17MMP2ADAMTS4MMP13MMP14 | |
| SCHEMBL6942498 | 0.77 | CTSK (0.39) | ADAM17ECE1FCER2PSMB5MMP1 | |
| SCHEMBL7100583 | 0.76 | ADAM17 (0.60) | ADAM17ECE1MMP2ADAMTS4MMP13 | |
| SCHEMBL7104743 | 0.74 | ADAM17 (0.58) | ADAM17ECE1MMP2ADAMTS4MMP13 | |
| SCHEMBL6937848 | 0.74 | ADAM17 (0.64) | ADAM17MMP2MMP13MMP14FCER2 | |
| SCHEMBL7101859 | 0.73 | ADAM17 (0.57) | ADAM17ECE1MMP2ADAMTS4MMP13 | |
| SCHEMBL6942613 | 0.73 | ADAM17 (0.68) | ADAM17MMP2MMP13MMP14FCER2 | |
| SCHEMBL6941952 | 0.73 | ADAM17 (0.65) | ADAM17MMP2ADAMTS4MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |