Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940822 | 0.80 | ADAM17 (0.56) | ADAM17MMP1PSMB5ADAMTS4MMP2 | |
| SCHEMBL6946515 | 0.79 | SLC1A3 (0.49) | MMP1PSMB5CTSKCA12CA2 | |
| SCHEMBL6946518 | 0.79 | SLC1A3 (0.49) | MMP1PSMB5CTSKCA12CA2 | |
| SCHEMBL6942960 | 0.79 | ADAM17 (0.43) | ADAM17MMP1PSMB5ADAMTS4MMP2 | |
| SCHEMBL6942387 | 0.77 | ADAM17 (0.71) | ADAM17MMP1MMP2MMP13MMP14 | |
| SCHEMBL6943886 | 0.72 | MMP1 (0.41) | ADAM17MMP1PSMB5MMP2MMP13 | |
| SCHEMBL6943883 | 0.72 | MMP1 (0.41) | ADAM17MMP1PSMB5MMP2MMP13 | |
| SCHEMBL6937848 | 0.72 | ADAM17 (0.64) | ADAM17MMP1MMP2MMP13MMP14 | |
| SCHEMBL6946654 | 0.71 | ADAM17 (0.53) | ADAM17MMP1PSMB5MMP2MMP13 | |
| SCHEMBL6941952 | 0.71 | ADAM17 (0.65) | ADAM17MMP1ADAMTS4MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |