Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | FCER2 | P06734 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941765 | 0.85 | ADAM17 (0.52) | ADAM17APPMMP3FCER2MMP1 | |
| SCHEMBL7076170 | 0.77 | MMP1 (0.49) | ADAM17MMP3FCER2MMP1 | |
| SCHEMBL6940822 | 0.77 | ADAM17 (0.56) | ADAM17ECE1FCER2PSMB5MMP1 | |
| SCHEMBL6939992 | 0.77 | ADAM17 (0.41) | ADAM17MMP3MMP1 | |
| SCHEMBL9714079 | 0.74 | ADAM17 (0.56) | ADAM17MMP3MMP1 | |
| SCHEMBL6939576 | 0.73 | ADAM17 (0.40) | ADAM17PSMB5MMP1POLB | |
| SCHEMBL9714088 | 0.73 | CTSK (0.39) | CTSKECE1APPPSMB5MMP1 | |
| SCHEMBL6942091 | 0.72 | ADAM17 (0.46) | ADAM17MMP3MMP1CTSB | |
| SCHEMBL6945858 | 0.71 | ADAM17 (0.57) | ADAM17MMP3MMP1 | |
| SCHEMBL6940945 | 0.69 | ADAM17 (0.75) | ADAM17MMP3FCER2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |