Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | FCER2 | P06734 | 2/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102324 | 0.92 | MMP8 (0.34) | ANPEPMMP8FCER2ADAM17MMP1 | |
| SCHEMBL7099916 | 0.82 | MMP8 (0.39) | ANPEPMMP8FCER2ADAM17TSHR | |
| SCHEMBL7100614 | 0.80 | MMP8 (0.37) | ANPEPMMP8FCER2ADAM17TSHR | |
| SCHEMBL7101371 | 0.80 | MMP8 (0.35) | ANPEPMMP8FCER2TSHRMMP1 | |
| SCHEMBL7100635 | 0.79 | GAA (0.37) | ANPEPMMP8FCER2ADAM17TSHR | |
| SCHEMBL6942520 | 0.77 | ADAM17 (0.41) | MMP8ADAM17MMP1MMP2MMP3 | |
| SCHEMBL6982649 | 0.76 | ANPEP (0.40) | ANPEPMMP8FCER2ADAM17TSHR | |
| SCHEMBL6941949 | 0.73 | ADAM17 (0.37) | ANPEPFCER2ADAM17MMP1MMP2 | |
| SCHEMBL6945575 | 0.72 | MMP2 (0.39) | MMP8ADAM17MMP1MMP2MMP3 | |
| SCHEMBL6942381 | 0.71 | ADAM17 (0.40) | ANPEPFCER2ADAM17MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | claimed |
| EP-1133471-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-19 | — | — | EP | claimed |
| US-6265446-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC.. | 2001-07-24 | — | — | US | claimed |
| WO-2000032570-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-08 | — | — | WO | claimed |
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| EP-1133471-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-19 | — | — | EP | disclosed |
| US-6265446-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC.. | 2001-07-24 | — | — | US | disclosed |
| WO-2000032570-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-08 | — | — | WO | disclosed |