SCHEMBL6942333

SCHEMBL6942333

CO[C@@H](COC(=O)C1=C(C)NC(C)=C(C(=O)OC[C@H](OC)c2ccccc2)C1c1cccc(F)c1F)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 6/20 0.49
CACNA1D Q01668 6/20 0.49
CACNA1S Q13698 6/20 0.49
CACNA1C Q13936 6/20 0.49
CYP1A2 P05177 3/20 0.46
NR1I2 O75469 3/20 0.46
ADORA3 P0DMS8 3/20 0.46
ABCB11 O95342 2/20 0.46
LMNA P02545 2/20 0.46
NR3C1 P04150 2/20 0.46
PGR P06401 2/20 0.46
ABCB1 P08183 2/20 0.46
CNR1 P21554 2/20 0.46
ADRA1A P35348 2/20 0.46
SCN1A P35498 2/20 0.46
PDE4D Q08499 2/20 0.46
SCN5A Q14524 2/20 0.46
SCN2A Q99250 2/20 0.46
SCN3A Q9NY46 2/20 0.46
ABCC4 O15439 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6942341 1.00 CACNA1F (0.49) CACNA1FCACNA1DCACNA1SCACNA1CCYP1A2
SCHEMBL6942336 0.97 CACNA1F (0.47) CACNA1FCACNA1DCACNA1SCACNA1CCYP1A2
SCHEMBL6942347 0.97 CACNA1F (0.47) CACNA1FCACNA1DCACNA1SCACNA1CCYP1A2
SCHEMBL6945825 0.97 CACNA1F (0.47) CACNA1FCACNA1DCACNA1SCACNA1CCYP1A2
SCHEMBL9765691 0.81 ABCB11 (0.59) CACNA1FCACNA1DCACNA1SCACNA1CCYP1A2
SCHEMBL3032439 0.81 MTOR (0.59) CACNA1CCYP1A2NR1I2ADORA3ABCB11
SCHEMBL13285115 0.79 CYP2C9 (0.67) CACNA1FCACNA1DCACNA1SCACNA1CCYP1A2
SCHEMBL6945817 0.78 ALOX15 (0.51) CYP1A2NR1I2ADORA3ABCB11LMNA
SCHEMBL7884089 0.78 NR1I2 (0.59) CACNA1FCACNA1DCACNA1SCACNA1CCYP1A2
SCHEMBL9765739 0.78 CACNA1D (0.68) CACNA1FCACNA1DCACNA1SCACNA1CCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0657431-B1 4-Phenyl-3-substituted 1,4-dihydropyridine esters with cerebral activity BAYER AG (DE) 2003-02-19 EP claimed
US-6066655-A FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, IN PARTICULAR AS CEREBRAL THERAPEUTICS BAYER AKTIENGESELLSCHAFT (DE) 2000-05-23 US disclosed
US-5731333-A LEARNING AND MEMORY ENHANCEMENT, ANTIDEPRESSANTS BAYER AKTIENGESELLSCHAFT (DE) 1998-03-24 US disclosed