Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 3/20 | 0.35 |
| ▸ | PYGM | P11217 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7241732 | 0.80 | MAPT (0.68) | MAPTTP53POLBALOX15 | |
| SCHEMBL6945774 | 0.78 | ALOX15 (0.44) | MAPTMEN1MAPK1KMT2AKDM4E | |
| SCHEMBL8084184 | 0.76 | MAPT (0.63) | MAPTTP53POLBALOX15 | |
| SCHEMBL9246654 | 0.76 | MAPT (0.62) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL6952044 | 0.74 | PYGM (0.50) | PYGLPYGMALOX15 | |
| SCHEMBL9246649 | 0.73 | MAPT (0.67) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL6952275 | 0.72 | NR3C2 (0.42) | TP53POLBKDM4EPYGLPYGM | |
| SCHEMBL9236145 | 0.72 | TP53 (0.44) | MAPTTP53TSHRPYGLPYGM | |
| SCHEMBL7247365 | 0.71 | MAPT (0.42) | MAPTTP53POLBMEN1MAPK1 | |
| SCHEMBL9215355 | 0.70 | PYGM (0.50) | TSHRSMN1; SMN2PYGLPYGM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657431-B1 | 4-Phenyl-3-substituted 1,4-dihydropyridine esters with cerebral activity | BAYER AG (DE) | 2003-02-19 | — | — | EP | disclosed |
| EP-0657431-A1 | 4-Phenyl-3-substituted 1,4-dihydropyridine esters with cerebral activity | BAYER AG (DE) | 1995-06-14 | — | — | EP | disclosed |