Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946924 | 0.87 | POLB (0.46) | ITGB3ITGA2BFFAR1TP53GRIN1 | |
| SCHEMBL7445046 | 0.84 | FFAR1 (0.48) | ITGB3ITGA2BFFAR1GRM5 | |
| SCHEMBL7445303 | 0.84 | DRD2 (0.41) | ITGB3ITGA2BFFAR1POLBALOX15 | |
| SCHEMBL6951468 | 0.81 | ITGB3 (0.46) | ITGB3ITGA2BFFAR1TP53POLB | |
| SCHEMBL7137255 | 0.78 | GRIN1 (0.41) | ITGB3ITGA2BFFAR1GRIN1SIGMAR1 | |
| SCHEMBL6420263 | 0.76 | ITGB3 (0.56) | ITGB3ITGA2BOPRM1OPRK1 | |
| SCHEMBL6420268 | 0.76 | ITGB3 (0.56) | ITGB3ITGA2BOPRM1OPRK1 | |
| SCHEMBL538358 | 0.74 | ITGB3 (0.39) | ITGB3ITGA2BOPRM1MDM2OPRK1 | |
| SCHEMBL538079 | 0.74 | ITGB3 (0.39) | ITGB3ITGA2BOPRM1MDM2OPRK1 | |
| SCHEMBL6951755 | 0.71 | ALOX15 (0.39) | POLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674623-B1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-04-09 | — | — | EP | disclosed |
| US-6403578-B1 | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| EP-0674623-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014776-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |