Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943055 | 0.91 | PIN1 (0.34) | CTSCMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6985696 | 0.91 | CTSC (0.35) | CTSCMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6943697 | 0.89 | MASP2 (0.34) | CTSCMEN1KMT2A | |
| SCHEMBL6987488 | 0.84 | ADAM17 (0.31) | CTSCGRIK1GRIK2ADAM17 | |
| SCHEMBL6986164 | 0.84 | ADAM17 (0.31) | CTSCGRIK1GRIK2ADAM17 | |
| SCHEMBL6940940 | 0.84 | ADAM17 (0.35) | CTSCMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6940166 | 0.84 | TGFBR1 (0.34) | — | |
| SCHEMBL6945559 | 0.84 | PIN1 (0.37) | CTSCMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6942465 | 0.83 | PIN1 (0.32) | CTSCMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6941574 | 0.82 | ADAM17 (0.38) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |