Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943055 | 0.91 | PIN1 (0.34) | PIN1CTSCLMNAL3MBTL1KMT2A | |
| SCHEMBL6945559 | 0.89 | PIN1 (0.37) | PIN1CTSCLMNAL3MBTL1KMT2A | |
| SCHEMBL6945039 | 0.84 | TGFBR1 (0.33) | — | |
| SCHEMBL6943697 | 0.84 | MASP2 (0.34) | CTSCKMT2AMEN1 | |
| SCHEMBL6940085 | 0.83 | MASP2 (0.33) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL6943182 | 0.83 | CTSC (0.34) | PIN1CTSCLMNAL3MBTL1KMT2A | |
| SCHEMBL6943537 | 0.82 | MMP1 (0.35) | PIN1LMNAKMT2AMEN1MAPT | |
| SCHEMBL6985696 | 0.81 | CTSC (0.35) | CTSCLMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL6940166 | 0.77 | TGFBR1 (0.34) | — | |
| SCHEMBL6987488 | 0.75 | ADAM17 (0.31) | CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |