Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.58 |
| ▸ | HTR2C | P28335 | 8/20 | 0.58 |
| ▸ | HTR2A | P28223 | 6/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | HTR1D | P28221 | 12/20 | 0.56 |
| ▸ | HTR1B | P28222 | 9/20 | 0.56 |
| ▸ | HTR2B | P41595 | 4/20 | 0.55 |
| ▸ | HTR1E | P28566 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | HTR5A | P47898 | 3/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.55 |
| ▸ | HTR3B | O95264 | 2/20 | 0.55 |
| ▸ | HTR1F | P30939 | 2/20 | 0.55 |
| ▸ | HTR3A | P46098 | 2/20 | 0.55 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29633081 | 0.89 | HTR1A (0.70) | HTR1AHTR2CHTR2ASLC6A4MPO | |
| SCHEMBL4055413 | 0.89 | HTR1A (0.70) | HTR1AHTR2CHTR2ASLC6A4MPO | |
| SCHEMBL7076438 | 0.88 | HTR1D (0.60) | HTR1AHTR2CHTR2ASLC6A4MPO | |
| SCHEMBL6945756 | 0.87 | HTR1D (0.50) | HTR1AHTR2CHTR2ASLC6A4MPO | |
| SCHEMBL7480335 | 0.84 | HTR1D (0.57) | HTR1AHTR2CHTR2ASLC6A4HTR1D | |
| SCHEMBL27374778 | 0.83 | MPO (0.61) | HTR1AHTR2CHTR2ASLC6A4MPO | |
| SCHEMBL7478879 | 0.82 | HTR1D (0.55) | HTR1AHTR2CHTR2ASLC6A4MPO | |
| SCHEMBL6942952 | 0.80 | HTR1A (0.56) | HTR1AHTR2CHTR2ASLC6A4MPO | |
| SCHEMBL7324823 | 0.79 | HTR1D (0.68) | HTR1AHTR2CHTR2ASLC6A4MPO | |
| SCHEMBL15701982 | 0.78 | HTR2A (0.70) | HTR1AHTR2CHTR2ASLC6A4MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | claimed |
| EP-0763032-B1 | PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE | MERCK & CO INC (US) | 2003-10-15 | — | — | EP | disclosed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | disclosed |