Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.60 |
| ▸ | MPO | P05164 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 6/20 | 0.59 |
| ▸ | HTR1A | P08908 | 5/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | HTR1B | P28222 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR1E | P28566 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27374778 | 0.93 | MPO (0.61) | HTR1DMPOHTR2AHTR1AHTR6 | |
| SCHEMBL6943874 | 0.88 | HTR1A (0.58) | HTR1DMPOHTR2AHTR1AHTR6 | |
| SCHEMBL24243738 | 0.83 | HTR2A (0.74) | HTR1DMPOHTR2AHTR1AHTR6 | |
| SCHEMBL7480335 | 0.82 | HTR1D (0.57) | HTR1DHTR2AHTR1AHTR6HTR1B | |
| SCHEMBL7478879 | 0.80 | HTR1D (0.55) | HTR1DMPOHTR2AHTR1AHTR6 | |
| SCHEMBL6945756 | 0.80 | HTR1D (0.50) | HTR1DMPOHTR2AHTR1AHTR6 | |
| SCHEMBL27373453 | 0.78 | ALDH1A1 (0.44) | HTR1DHTR2AHTR1AHTR6HTR1B | |
| SCHEMBL24243715 | 0.78 | HTR2A (0.72) | HTR1DMPOHTR2AHTR1AHTR6 | |
| SCHEMBL4055413 | 0.76 | HTR1A (0.70) | HTR1DMPOHTR2AHTR1AHTR6 | |
| SCHEMBL29633081 | 0.76 | HTR1A (0.70) | HTR1DMPOHTR2AHTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | claimed |
| EP-0763032-B1 | PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE | MERCK & CO INC (US) | 2003-10-15 | — | — | EP | disclosed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | disclosed |