Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Olopatadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | PARP1 | P09874 | 1/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.65 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.65 |
| ▸ | DRD1 | P21728 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 1/20 | 0.65 |
| ▸ | DRD5 | P21918 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olopatadine SCHEMBL694414 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KCNH2HTR2B | |
| Olopatadine SCHEMBL693865 | 0.99 | HRH1 (0.96) | HRH1LMNAPARP1KCNH2ALDH1A1 | |
| Olopatadine SCHEMBL693866 | 0.99 | HRH1 (0.96) | HRH1LMNAPARP1KCNH2ALDH1A1 | |
| Olopatadine SCHEMBL4669 | 0.99 | HRH1 (1.00) | HRH1LMNAPARP1KCNH2HTR2B | |
| Olopatadine SCHEMBL29359369 | 0.99 | HRH1 (1.00) | HRH1LMNAPARP1KCNH2HTR2B | |
| Olopatadine SCHEMBL29517420 | 0.99 | HRH1 (1.00) | HRH1LMNAPARP1KCNH2HTR2B | |
| Olopatadine SCHEMBL4668 | 0.99 | HRH1 (1.00) | HRH1LMNAPARP1KCNH2HTR2B | |
| Olopatadine SCHEMBL1649764 | 0.99 | HRH1 (1.00) | HRH1LMNAPARP1KCNH2HTR2B | |
| Olopatadine SCHEMBL23213 | 0.98 | HRH1 (0.98) | HRH1LMNAPARP1KCNH2ALDH1A1 | |
| Olopatadine SCHEMBL122589 | 0.98 | HRH1 (0.98) | HRH1LMNAPARP1KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871953-B2 | Process for the preparation of olopatadine | F.I.S. Fabbrica Italiana Sintetiei S.p.A. (IT) | 2014-10-28 | — | — | US | claimed |
| EP-2421843-B1 | PROCESS FOR THE PREPARATION OF OLOPATADINE | ITALIANA SINT SPA (IT) | 2014-04-30 | — | — | EP | claimed |
| EP-2421843-A2 | PROCESS FOR THE PREPARATION OF OLOPATADINE | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2012-02-29 | — | — | EP | claimed |
| US-20110065936-A1 | PROCESS FOR THE PREPARATION OF OLOPATADINE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2011-03-17 | — | — | US | claimed |
| WO-2010121877-A2 | PROCESS FOR THE PREPARATION OF OLOPATADINE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2010-10-28 | — | — | WO | claimed |
| US-7687646-B2 | Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof | AZAD PHARMACEUTICAL INGREDIENTS, AG (CH) | 2010-03-30 | — | — | US | claimed |
| EP-2004621-A2 | POLYMORPHIC FORMS OF OLOPATADINE HYDROCHLORIDE AND METHODS FOR PRODUCING OLOPATADINE AND SALTS THEREOF | Universität Zürich (CH) | 2008-12-24 | — | — | EP | claimed |
| WO-2007110761-A2 | POLYMORPHIC FORMS OF OLOPATADINE HYDROCHLORIDE AND METHODS FOR PRODUCING OLOPATADINE AND SALTS THEREOF | Universität Zürich (CH) | 2007-10-04 | — | — | WO | claimed |
| US-20070232814-A1 | Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof | UNIVERSITAT ZURICH (CH) | 2007-10-04 | — | — | US | claimed |
| US-8980939-B2 | Process for the preparation of olopatadine | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-03-17 | — | — | US | disclosed |
| US-8871953-B2 | Process for the preparation of olopatadine | F.I.S. Fabbrica Italiana Sintetiei S.p.A. (IT) | 2014-10-28 | — | — | US | disclosed |
| EP-2421843-B1 | PROCESS FOR THE PREPARATION OF OLOPATADINE | ITALIANA SINT SPA (IT) | 2014-04-30 | — | — | EP | disclosed |
| US-20140024704-A1 | PROCESS FOR THE PREPARATION OF OLOPATADINE | ITALIANA SINT SPA (IT) | 2014-01-23 | — | — | US | disclosed |
| EP-2421843-A2 | PROCESS FOR THE PREPARATION OF OLOPATADINE | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121877-A2 | PROCESS FOR THE PREPARATION OF OLOPATADINE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2010-10-28 | — | — | WO | disclosed |
| US-7687646-B2 | Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof | AZAD PHARMACEUTICAL INGREDIENTS, AG (CH) | 2010-03-30 | — | — | US | disclosed |
| WO-2009081417-A2 | PROCESS FOR PREPARATION OF OLOPAT ADINE HYDROCHLORIDE | INDOCO REMEDIES LIMITED (IN) | 2009-07-02 | — | — | WO | disclosed |
| EP-2004621-A2 | POLYMORPHIC FORMS OF OLOPATADINE HYDROCHLORIDE AND METHODS FOR PRODUCING OLOPATADINE AND SALTS THEREOF | Universität Zürich (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007110761-A2 | POLYMORPHIC FORMS OF OLOPATADINE HYDROCHLORIDE AND METHODS FOR PRODUCING OLOPATADINE AND SALTS THEREOF | Universität Zürich (CH) | 2007-10-04 | — | — | WO | disclosed |
| US-20070232814-A1 | Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof | UNIVERSITAT ZURICH (CH) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232814-A1 | Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof | HRH4, HRH1, HRH3 | HRH1 2/4885LMNA 4846/4885PARP1 844/4885 |
| US-20140024704-A1 | PROCESS FOR THE PREPARATION OF OLOPATADINE | ADRA2A, ADRA1B, OPRK1 | HRH1 64/4885LMNA 3773/4885PARP1 204/4885 |
| US-20110065936-A1 | PROCESS FOR THE PREPARATION OF OLOPATADINE | OPRK1, QDPR, ADRA1B | HRH1 53/4885LMNA 4330/4885PARP1 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.