Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.44 |
| ▸ | MMP3 | P08254 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940310 | 0.86 | MMP3 (0.44) | MMP2MMP3GAASMN1; SMN2LMNA | |
| SCHEMBL6986672 | 0.73 | MMP1 (0.44) | MMP3MMP1MMP13MMP8 | |
| SCHEMBL7853162 | 0.71 | MMP1 (0.46) | MMP3MMP1MMP13MMP8MAPT | |
| SCHEMBL7853167 | 0.71 | MMP1 (0.46) | MMP3MMP1MMP13MMP8MAPT | |
| SCHEMBL7836454 | 0.71 | MMP1 (0.46) | MMP3MMP1MMP13MMP8MAPT | |
| SCHEMBL7827850 | 0.71 | MMP1 (0.46) | MMP3MMP1MMP13MMP8MAPT | |
| SCHEMBL9714201 | 0.71 | ADAM17 (0.67) | MMP2MMP3MMP1MMP13MMP8 | |
| SCHEMBL7855580 | 0.69 | MMP1 (0.62) | MMP2MMP3MMP1MMP13MMP8 | |
| SCHEMBL6943287 | 0.68 | MMP3 (0.45) | MMP3LMNAMMP1MMP8MAPT | |
| SCHEMBL6943292 | 0.68 | MMP3 (0.45) | MMP3LMNAMMP1MMP8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |