Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 10/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460733 | 0.90 | LMNA (0.52) | ADRB3ADRB1ADRB2HRH3LMNA | |
| SCHEMBL7469004 | 0.87 | ADRB3 (0.52) | ADRB3ADRB1ADRB2HRH3LMNA | |
| SCHEMBL7473044 | 0.87 | ADRB3 (0.52) | ADRB3ADRB1ADRB2HRH3LMNA | |
| SCHEMBL6953116 | 0.84 | ADRB1 (0.56) | ADRB3ADRB1ADRB2LMNAMEN1 | |
| SCHEMBL7473303 | 0.84 | ADRB3 (0.58) | ADRB3ADRB1ADRB2LMNA | |
| SCHEMBL7854359 | 0.84 | HRH3 (0.45) | ADRB3ADRB1HRH3JAK2JAK1 | |
| SCHEMBL6951393 | 0.83 | ADRB1 (0.57) | ADRB3ADRB1ADRB2 | |
| SCHEMBL7469736 | 0.82 | ADRB3 (0.53) | ADRB3ADRB1ADRB2LMNAALDH1A1 | |
| SCHEMBL6945509 | 0.80 | ADRB1 (0.58) | ADRB3ADRB1ADRB2LMNAMEN1 | |
| SCHEMBL7560376 | 0.79 | LMNA (0.56) | ADRB3ADRB1ADRB2HRH3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649627-B1 | N-Substituted with 1- (pyrid-2-yl)-piperidine-4-yl radical; gastrointestinal and psychological disorder treatment; antidiabetic tocolytic, and antidepressant agents; irritable bowel syndrome, glaucoma and dysmenorrhoea | SANOFI-SYNTHELABO (FR) | 2003-11-18 | — | — | US | disclosed |
| EP-1087961-B1 | PHENOXYLPROPANOLAMINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SANOFI SYNTHELABO (FR) | 2002-08-14 | — | — | EP | disclosed |