SCHEMBL694542

SCHEMBL694542

COc1c(Cl)ccc(-c2cc(N)c(Cl)c(C(=O)NOCc3cnc(Cl)s3)n2)c1F

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
MAPT P10636 2/20 0.37
LMNA P02545 1/20 0.37
KDM4E B2RXH2 3/20 0.34
L3MBTL1 Q9Y468 4/20 0.34
ALOX12 P18054 1/20 0.34
ALDH1A1 P00352 3/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
RECQL P46063 1/20 0.33
ALOX5AP P20292 1/20 0.32
FEN1 P39748 1/20 0.32
POLB P06746 1/20 0.32
GAA P10253 1/20 0.32
KLKB1 P03952 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL694656 0.89 HTT (0.38) LMNASMN1; SMN2ALOX5APFEN1KLKB1
SCHEMBL694248 0.84 MEP1B (0.35) LMNAKDM4EALDH1A1SMN1; SMN2GAA
SCHEMBL694666 0.84 MEP1B (0.35) KDM4EALDH1A1GAAKLKB1
SCHEMBL694228 0.84 ALOX5AP (0.42) L3MBTL1ALDH1A1ALOX5APFEN1
SCHEMBL694177 0.84 RAB9A (0.40) KMT2AMEN1L3MBTL1SMN1; SMN2ALOX5AP
SCHEMBL693814 0.84 ATM (0.37) L3MBTL1ALDH1A1SMN1; SMN2ALOX5APFEN1
SCHEMBL693815 0.84 ALDH1A1 (0.35) LMNAKDM4EALDH1A1SMN1; SMN2GAA
SCHEMBL694488 0.83 ATM (0.42) MAPTLMNAL3MBTL1ALOX5APFEN1
SCHEMBL695093 0.83 NPC1 (0.40) KMT2AMAPTLMNAL3MBTL1ALDH1A1
SCHEMBL694608 0.83 KLKB1 (0.32) ALOX5APFEN1KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 US claimed
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 US disclosed
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 US disclosed
US-20130324412-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2013-12-05 US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 US disclosed
EP-2421832-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS Dow AgroSciences LLC (US) 2012-02-29 EP disclosed
WO-2010099279-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 WO disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 US disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 US disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS HASPIN, NOTUM, CANX KMT2A 1099/4885MEN1 4849/4885MAPT 2035/4885
US-20130324412-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS NPEPPS, DNPEP, HASPIN KMT2A 706/4885MEN1 4834/4885MAPT 2562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.