Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 10/20 | 0.49 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951305 | 0.77 | MGAT2 (0.60) | PKLRPOLB | |
| SCHEMBL10836333 | 0.76 | TBXAS1 (0.71) | TBXAS1KDM4E | |
| SCHEMBL27713238 | 0.74 | TDP1 (0.70) | TBXAS1GAA | |
| SCHEMBL15823476 | 0.74 | PRMT1 (0.69) | TBXAS1KDM4E | |
| Hydrochloric Acid SCHEMBL1238218 | 0.73 | TDP1 (0.68) | TBXAS1GAA | |
| SCHEMBL6943633 | 0.73 | ALDH1A1 (0.58) | PKLRIDO1GAAKDM4EPOLB | |
| SCHEMBL7812463 | 0.73 | MGAT2 (0.56) | PKLRPOLB | |
| SCHEMBL6947428 | 0.73 | PKLR (0.52) | PKLRIDO1GAAKDM4EPOLB | |
| SCHEMBL15823527 | 0.71 | CA1 (0.61) | TBXAS1 | |
| SCHEMBL7670526 | 0.70 | CHRNA7 (0.49) | TBXAS1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |